Beginning with MySQL 3.23.16, the
          mysqld-max and
          mysql-max-nt servers for Windows are
          compiled with the -DUSE_SYMDIR option. This
          enables you to put a database directory on a different disk by
          setting up a symbolic link to it. This is similar to the way
          that symbolic links work on Unix, although the procedure for
          setting up the link is different.
        
          It is necessary to define USE_SYMDIR
          explicitly only before MySQL 4.0; for
          mysqld-max and
          mysql-max-nt, you can enable symbolic links
          by using the --symbolic-links
          option. As of MySQL 4.0, symbolic links are enabled by default
          for all Windows servers. If you do not need them, you can
          disable them with the
          --skip-symbolic-links
          option.
        
          On Windows, create a symbolic link to a MySQL database by
          creating a file in the data directory that contains the path
          to the destination directory. The file should be named
          db_name.symdb_name is the database name.
        
          Suppose that the MySQL data directory is
          C:\mysql\data and you want to have
          database foo located at
          D:\data\foo. Set up a symlink using this
          procedure:
        
              Make sure that the D:\data\foo
              directory exists by creating it if necessary. If you
              already have a database directory named
              foo in the data directory, you should
              move it to D:\data. Otherwise, the
              symbolic link will be ineffective. To avoid problems, make
              sure that the server is not running when you move the
              database directory.
            
              Create a text file
              C:\mysql\data\foo.sym that contains
              the path name D:\data\foo\.
            
                The path name to the new database and tables should be
                absolute. If you specify a relative path, the location
                will be relative to the foo.sym
                file.
              
          After this, all tables created in the database
          foo are created in
          D:\data\foo.
        
          The following limitations apply to the use of
          .sym files for database symbolic linking
          on Windows:
        
The symbolic link is not used if a directory with the same name as the database exists in the MySQL data directory.
              The --innodb_file_per_table
              option cannot be used.
            
              If you run mysqld as a service, you
              cannot use a mapped drive to a remote server as the
              destination of the symbolic link. As a workaround, you can
              use the full path
              (\\servername\path\).
            


User Comments
You can also Mount any NTFS Partition to an empty folder with the disk management tool. In this case your Database folder.
For step-by-step instructions on Mounting a partition:
http://support.microsoft.com/kb/307889
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